Microfluidic self-assembly of high cabazitaxel loading albumin nanoparticles. Issue 32 (10th August 2020)

• Record Type: Journal Article
• Authors: Sun, Yating; Lee, Robert J.; Meng, Fanchao; Wang, Guiyuan; Zheng, Xiaolong; Dong, Shiyan; Teng, Lesheng
• Is Part Of: Nanoscale. Volume 12:Issue 32(2020)
• Page Start: 16928
• Page End: 16933
• Publication Date: 2020-08-10
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr10941b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Microfluidic technology for the preparation of human serum albumin nanoparticles is a promising method. Abstract : Cabazitaxel (CTX) is a promising anticancer drug. In this study, CTX-loaded human serum albumin (HSA) nanoparticles (MF-NPs-CTX) were prepared by a microfluidic (MF) method and were evaluated for tumor inhibition in PC-3 and HeLa cells in vitro and in vivo . The in vitro experiments showed that MF-NPs-CTX had higher drug loading content (DLC) as compared with NPs prepared by the bottom-up (BU) method (BU-NPs-CTX). Besides, MF-NPs-CTX exhibited uniform particle size distribution, high stability, sustained drug release, and high biosafety, in vivo imaging studies demonstrated that MF-NPs-CTX accumulated preferentially at the tumor site, compared to BU-NPs-CTX. The enhanced tumor uptake also increased the therapeutic efficacy of MF-NPs-CTX. Both MF-NPs-CTX and tween-CTX exhibited good tumor inhibition effect in vivo . MF-NPs-CTX had better biosafety and biocompatibility than tween-CTX. These results demonstrated that high CTX loading of MF-NPs-CTX has potential in the clinical treatment of tumors.