Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides. Issue 67 (23rd July 2020)
- Record Type:
- Journal Article
- Title:
- Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides. Issue 67 (23rd July 2020)
- Main Title:
- Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides
- Authors:
- Wang, Lei
Okamura, Hidenori
Sasaki, Shigeki
Taniguchi, Yosuke - Abstract:
- Abstract : Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands. Abstract : We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.
- Is Part Of:
- Chemical communications. Volume 56:Issue 67(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 67(2020)
- Issue Display:
- Volume 56, Issue 67 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 67
- Issue Sort Value:
- 2020-0056-0067-0000
- Page Start:
- 9731
- Page End:
- 9734
- Publication Date:
- 2020-07-23
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc04240d ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13885.xml