Copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes: synthesis of fully substituted indoles. Issue 68 (24th July 2020)

• Record Type: Journal Article
• Authors: Yu, Yang; Wang, Xin-Yu; Peng, Ju-Yin; Liu, Tao; Zhao, Yu-Long
• Is Part Of: Chemical communications. Volume 56:Issue 68(2020)
• Page Start: 9815
• Page End: 9818
• Publication Date: 2020-07-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc00512f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed. This reaction provides a new method for the synthesis of fully substituted indoles by formation of four new bonds and two rings in a single step. Abstract : A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed for the first time. This reaction provides a new and highly efficient method for the synthesis of fully substituted indoles by formation of four new bonds and two rings from readily available starting materials in a single step.