A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring. Issue 69 (28th July 2020)

• Record Type: Journal Article
• Authors: Singh, Amit Kumar; Kundu, Moumita; Roy, Samrat; Roy, Biswajit; Shah, Sk. Sheriff; Nair, Asha V; Pal, Bipul; Mondal, Mahitosh; Singh, N. D. Pradeep
• Is Part Of: Chemical communications. Volume 56:Issue 69(2020)
• Page Start: 9986
• Page End: 9989
• Publication Date: 2020-07-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc01903h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release. Abstract : We report a two-photon responsive drug delivery system (DDS), namely, p -hydroxyphenacyl–naphthalene–chlorambucil ( p HP–Naph–Cbl ), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.