Organic–inorganic nanocrystal reductase to promote green asymmetric synthesis. Issue 51 (20th August 2020)

• Record Type: Journal Article
• Authors: T.sriwong, Kotchakorn; Koesoema, Afifa Ayu; Matsuda, Tomoko
• Is Part Of: RSC advances. Volume 10:Issue 51(2020)
• Page Start: 30953
• Page End: 30960
• Publication Date: 2020-08-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra03160g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Geotrichum candidum acetophenone reductase ( Gc APRD) nanocrystal reduces broad kinds of ketones to their corresponding ( S )-alcohols with excellent enantioselectivity. Abstract : An acetophenone reductase from Geotrichum candidum ( Gc APRD) was immobilized by the organic–inorganic nanocrystal method. The Gc APRD nanocrystal presented improved stability and recyclability compared with those of the free Gc APRD. Moreover, the Gc APRD nanocrystal reduced broad kinds of ketones with excellent enantioselectivities to produce beneficial chiral alcohols such as ( S )-1-(3′, 4′-dichlorophenyl)ethanol with >99% yield and >99% ee. The robust and versatile properties of the Gc APRD nanocrystal demonstrated an approach to promote green asymmetric synthesis and sustainable chemistry.