Iron catalyzed ketoalkylation and ketoalkylation/etherification of styrenes initiated by selective C–C bond cleavage. Issue 17 (27th July 2020)

• Record Type: Journal Article
• Authors: Suo, Meng-Ting; Yang, Shuo; Yang, Jun-Cheng; Liu, Ze-Yu; Zhang, Jun-Jie; Guo, Li-Na
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 17(2020)
• Page Start: 2414
• Page End: 2418
• Publication Date: 2020-07-27
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00671h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A mild and efficient iron-catalyzed ketoalkyl-Heck-type coupling initiated by radical C–C bond cleavage is described. Furthermore, this concise catalytic system was also applicable for the three-component ketoalkylation/etherification of styrenes. Abstract : An iron-catalyzed ketoalkyl-Heck-type coupling initiated by radical C–C bond cleavage is described. The features of this protocol include mild conditions (40 °C, free of ligands and bases), broad substrate scope, excellent functional group tolerance and stereoselectivity. Satisfactorily, this Fe-based catalytic system was also applicable for the three-component ketoalkylation/etherification of styrenes.