Seroprevalence of H7N9 infection among humans: A systematic review and meta‐analysis. Issue 5 (10th March 2020)

• Record Type: Journal Article
• Authors: Wang, Qiang; Xu, Ke; Xie, Weihua; Yang, Liuqing; Chen, Haiyan; Shi, Naiyang; Bao, Changjun; Huang, Haodi; Zhang, Xuefeng; Liao, Yilan; Jin, Hui
• Is Part Of: Influenza and other respiratory viruses. Volume 14:Issue 5(2020)
• Page Start: 587
• Page End: 595
• Publication Date: 2020-03-10
• Subjects: H7N9 -- influenza A -- meta‐analysis -- seroprevalence -- systematic review; Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12736
• Languages: English
• ISSNs: 1750-2640

Abstract

Abstract: In spring 2013, a novel avian‐origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta‐analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman‐Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta‐analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high‐risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.