Rhodium‐Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Carbonyl‐Activated Alkenyl Azaarenes. Issue 15 (8th April 2020)

• Record Type: Journal Article
• Authors: Zhu, Huilong; Yin, Long; Chang, Zhiqian; Wang, Yuhan; Dou, Xiaowei
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 15(2020)
• Page Start: 3142
• Page End: 3147
• Publication Date: 2020-04-08
• Subjects: Asymmetric Catalysis -- Conjugate Addition -- Rhodium -- Organoboronic Acid -- Azaarene; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000211
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The enantioselective synthesis of chiral azaarenes by rhodium‐catalyzed asymmetric conjugate addition of organoboronic acids to carbonyl‐activated alkenyl azaarenes was reported. Diverse chiral azaarenes were produced in up to 99% yield and with up to 99% ee (>60 examples). Catalytic asymmetric syntheses of dexchlorpheniramine and dexbrompheniramine were realized by using the developed method. Abstract :