Can Environmental Manipulation Help Suppress Cancer? Non‐Linear Competition Among Tumor Cells in Periodically Changing Conditions. Issue 16 (1st July 2020)

• Record Type: Journal Article
• Authors: Babajanyan, S. G.; Koonin, Eugene V.; Cheong, Kang Hao
• Is Part Of: Advanced science. Volume 7:Issue 16(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-01
• Subjects: cancer suppression -- cancer treatment -- evolutionary dynamics -- game theory -- non‐linear dynamics -- population dynamics -- predatory–prey; Science -- Periodicals; 505
• DOI: 10.1002/advs.202000340
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: It has been shown that the tumor population growth dynamics in a periodically varying environment can drastically differ from the one in a fixed environment. Thus, the environment of a tumor can potentially be manipulated to suppress cancer progression. Diverse evolutionary processes play vital roles in cancer progression and accordingly, understanding the interplay between these processes is essential in optimizing the treatment strategy. Somatic evolution and genetic instability result in intra‐tumor cell heterogeneity. Various models have been developed to analyze the interactions between different types of tumor cells. Here, models of density‐dependent interaction between different types of tumor cells under fast periodical environmental changes are examined. It is illustrated that tumor population densities, which vary on a slow time scale, are affected by fast environmental variations. Finally, the intriguing density‐dependent interactions in metastatic castration‐resistant prostate cancer (mCRPC) in which the different types of tumor cells are defined with respect to the production of and dependence on testosterone are discussed. Abstract : The models of density‐dependent interaction between different types of tumor cells under fast periodical environmental changes are examined. Non‐linear dynamical effects in the tumor growth process are discovered. These dynamical effects can be manipulated for controlling the tumor growth process. The density‐dependent interactions in metastatic castrate‐resistant prostate cancer are also discussed.