Poly‐3‐hydroxybutyrate‐based constructs with novel characteristics for drug delivery and tissue engineering applications—A review. Issue 8 (8th July 2020)

• Record Type: Journal Article
• Authors: Sosa‐Hernández, Juan Eduardo; Villalba‐Rodríguez, Angel M.; Romero‐Castillo, Kenya D.; Zavala‐Yoe, Ricardo; Bilal, Muhammad; Ramirez‐Mendoza, Ricardo A.; Parra‐Saldivar, Roberto; Iqbal, Hafiz M. N.
• Is Part Of: Polymer engineering & science. Volume 60:Issue 8(2020)
• Page Start: 1760
• Page End: 1772
• Publication Date: 2020-07-08
• Subjects: biomaterials -- biomedicine -- drug carriers -- nanostructures -- P3HB -- polyhydroxyalkanoates -- tissue regeneration; Polymer engineering -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1002/pen.25470
• Languages: English
• ISSNs: 0032-3888

Abstract

Abstract: Herein, we reviewed polymeric constructs of polyhydroxyalkanoates (PHAs) at large and poly‐3‐hydroxybutyrate (P3HB), in particular, for drug delivery and tissue engineering applications. Polymeric constructs that can efficiently respond to numerous variations in their surroundings have gained notable attention from different industrial sectors such as biomedical, clinical, pharmaceutical, and cosmeceutical. Among them, considerable importance is given to their drug delivery and tissue engineering applications. PHAs with peculiar reference to P3HB are gaining prominence attention as candidate materials with such requisite potentialities. The unique structural and functional characteristics of PHAs and P3HB are of supreme interest and being used to engineer novel constructs for efficient drug delivery and tissue regeneration purposes. So far, an array of methodological approaches, such as in vitro, in vivo, and ex vivo techniques have been exploited though using different materials with different geometries for a said purpose. However, a low‐level production majorly limits their proper exploitation. Various physiochemical characteristics and production strategies have been introduced in this review. The data have been summarized on PHAs production by several microorganisms aiming to cover the scope of the last 10 years. The present review highlights the recent applications of PHAs and P3HB‐based constructs, such as micro/nanoparticles, biocomposite, nanofibers, and hydrogels as novel drug carries for regenerative medicine and tissue engineering. In summary, drug delivery and tissue engineering potentialities of PHAs and P3HB‐based constructs are discussed with suitable examples and envisioned directions of future developments. Abstract : Polymeric constructs of polyhydroxyalkanoates at large and poly‐3‐hydroxybutyrate, in particular, for drug delivery and tissue engineering applications. Polymeric constructs that can efficiently respond to numerous variations in their surroundings have gained notable attention from different industrial sectors such as biomedical, clinical, pharmaceutical, and cosmeceutical.