Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing. Issue 33 (23rd June 2020)

• Record Type: Journal Article
• Authors: Hu, Jingjie; Altun, Izzet; Zhang, Zefu; Albadawi, Hassan; Salomao, Marcela A.; Mayer, Joseph L.; Hemachandra, L. P. Madhubhani P.; Rehman, Suliman; Oklu, Rahmi
• Is Part Of: Advanced materials. Volume 32:Issue 33(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-23
• Subjects: decellularized extracellular matrix -- embolization -- hybrid nanocomposite hydrogels -- transcatheter delivery -- vascular remodeling; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202002611
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Transcatheter embolization is a minimally invasive procedure that uses embolic agents to intentionally block diseased or injured blood vessels for therapeutic purposes. Embolic agents in clinical practice are limited by recanalization, risk of non‐target embolization, failure in coagulopathic patients, high cost, and toxicity. Here, a decellularized cardiac extracellular matrix (ECM)‐based nanocomposite hydrogel is developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization. The embolic efficacy of the shear‐thinning ECM‐based hydrogel is shown in a porcine survival model of embolization in the iliac artery and the renal artery. The ECM‐based hydrogel promotes arterial vessel wall remodeling and a fibroinflammatory response while undergoing significant biodegradation such that only 25% of the embolic material remains at 14 days. With its unprecedented proregenerative, antibacterial properties coupled with favorable mechanical properties, and its superior performance in anticoagulated blood, the ECM‐based hydrogel has the potential to be a next‐generation biofunctional embolic agent that can successfully treat a wide range of vascular diseases. Abstract : A biohybrid hydrogel composed of cardiac‐derived extracellular matrix (ECM) and nanoclay (NC) is developed as a multifunctional embolic biomaterial that offers both the biological activity and the mechanical support necessary for successful arterial embolization. The shear‐thinning ECM–NC hydrogel exhibits excellent transcatheter injectability, retrievability, and proangiogenic characteristics to serve as a catheter‐directed bioactive embolic agent for the treatment of a variety of vascular diseases.