Facial rejuvenation using stem cell conditioned media combined with skin needling: A split‐face comparative study. (21st July 2020)

• Record Type: Journal Article
• Authors: El‐Domyati, Moetaz; Moftah, Noha H.; Nasif, Ghada A.; Ameen, Sameh W.; Ibrahim, Michel R.; Ragaie, Maha H.
• Is Part Of: Journal of cosmetic dermatology. Volume 19:Number 9(2020)
• Page Start: 2404
• Page End: 2410
• Publication Date: 2020-07-21
• Subjects: amniotic fluid stem cells products -- dermaroller -- facial aging -- skin needling; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.13594
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: The use of stem cells derived growth factors is representing a novel treatment modality in facial rejuvenation. Nowadays, skin needling is considered a very famous treatment of skin aging. However, the addition of such derived products, augments its therapeutic efficacy in the management and delay of skin aging. Objective: Comparing the effect of amniotic fluid mesenchymal stem cell derived conditioned media (AF‐MSC‐CM) combined with skin needling versus the needling alone in the management of facial aging. Methods: Both sides of the face of ten volunteers, suffering from facial aging, were treated with five sessions of skin needling, 2 weeks apart. After skin microneedling, AF‐MSC‐CM was added topically to the right side only. Clinical, histological, and morphometrical assessment of the treated skin was done at 1 month after the last session. Results: The percentage of improvement of aged skin increased significantly on the combined treated side (AF‐MSC‐CM and dermaroller [DR]), when compared with the other side (DR only) ( P < .001). Remodeling of the dermal structures was observed mainly on the combined side. Meanwhile, histometry of the epidermis revealed a significant increase in the epidermal thickness on both treated sides. Conclusion: AF‐MSC‐CM combined with skin needling was more efficient in managing facial aging than skin needling alone.