Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment. Issue 29 (12th March 2020)

• Record Type: Journal Article
• Authors: Pahattuge, Thilanga N.; Jackson, J. Matt; Digamber, Rane; Wijerathne, Harshani; Brown, Virginia; Witek, Malgorzata A.; Perera, Chamani; Givens, Richard S.; Peterson, Blake R.; Soper, Steven A.
• Is Part Of: Chemical communications. Volume 56:Issue 29(2020)
• Page Start: 4098
• Page End: 4101
• Publication Date: 2020-03-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09598e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400–450 nm). Abstract : We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400–450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.