Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization. Issue 36 (2nd April 2020)

• Record Type: Journal Article
• Authors: Pan, Zhiqiang; Liu, Yuchang; Hu, Fengchi; Liu, Qinglong; Shang, Wenbin; Xia, Chengfeng
• Is Part Of: Chemical communications. Volume 56:Issue 36(2020)
• Page Start: 4930
• Page End: 4933
• Publication Date: 2020-04-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc00847h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A process for the α-carboxyalkylation of tryptophols and tryptamines by the functionalization of C–H bonds under visible light irradiation has been developed. Abstract : A process for the α-carboxyalkylation of tryptophols and tryptamines by the functionalization of C–H bonds under visible light irradiation has been developed. The photochemical strategy activated the C–Br bonds of α-bromo-alkylcarboxylic esters to provide carbon-centered radicals under the catalysis of Ir(iii ) photocatalyst and coupled with indole derivatives. This methodology displayed wide functional group tolerance and excellent regioselectivity, and was applied to the late-stage functionalization and preparation of indole-containing hybrids.