Efficient synthesis of cyclic amidine-based fluorophores via 6π-electrocyclic ring closure. Issue 14 (13th March 2020)

• Record Type: Journal Article
• Authors: Li, Guofeng; Zhao, Man; Xie, Junqiu; Yao, Ying; Mou, Lingyun; Zhang, Xiaowei; Guo, Xiaomin; Sun, Wangsheng; Wang, Zheng; Xu, Jiecheng; Xue, Jianzhong; Hu, Tao; Zhang, Ming; Li, Min; Hong, Liang
• Is Part Of: Chemical science. Volume 11:Issue 14(2020)
• Page Start: 3586
• Page End: 3591
• Publication Date: 2020-03-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc00798f
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Novel 10π-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6π-electrocyclic ring closure of ketenimine and imine starting from N -sulfonyl triazoles and arylamines. Abstract : Novel 10π-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6π-electrocyclic ring closure of ketenimine and imine starting from N -sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.