Purine-blended nanofiber woven flexible nanomats for SERS-based analyte detection. Issue 43 (23rd April 2020)

• Record Type: Journal Article
• Authors: Saravanan, R. Kamal; Naqvi, Tania K.; Patil, Sandip; Dwivedi, Prabhat K.; Verma, Sandeep
• Is Part Of: Chemical communications. Volume 56:Issue 43(2020)
• Page Start: 5795
• Page End: 5798
• Publication Date: 2020-04-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc00648c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report a fabricated nanocomposite as a flexible Surface-Enhanced Raman Scattering (SERS) substrate for uric acid detection up to 10 −7 M (100 nM). Abstract : Flexible and free-standing polymeric fibers, coupled with metal nanoparticles, present an excellent opportunity for highly sensitive surface-enhanced Raman scattering (SERS) spectroscopy-based detection platforms. Such host matrices are prepared by only a few preferred methods, followed by induction of metal nanoparticle aggregation in a protected environment to afford functional SERS platforms. We provide an interesting advance in this area by choosing a thiol-modified purine (L )–polymer blend, obtained through the electrospinning process, for directed decoration with gold nanoparticles. The described SERS purine-nanomat substrate enables the detection of uric acid, an important indicator of gout, preeclampsia, cardiovascular and kidney diseases, in aqueous solution up to 100 nM, with good stability and high sensitivity, offering superiority over existing techniques in terms of sensitivity and cost-effectiveness.