Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes. Issue 16 (24th October 2019)

• Record Type: Journal Article
• Authors: Ma, Dik-Lung; Wu, Chun; Liu, Hao; Wu, Ke-Jia; Leung, Chung-Hang
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 16(2020)
• Page Start: 3249
• Page End: 3260
• Publication Date: 2019-10-24
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb01889a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Abnormally expressed receptor proteins are proved to be one of the crucial biomarkers for specific human diseases. Transitional metal based strategies possess delightful strengths in the in-field and real-time visualization of receptor proteins. Abstract : Protein biomarkers, particularly abnormally expressed receptor proteins, have been proved to be one of the crucial biomarkers for the rapid assessment, diagnosis, prognosis and prediction of specific human diseases. Transition metal based strategies in particular possess delightful strengths in the in-field and real-time visualization of receptor proteins owing to their unique photophysical properties. In this review, we highlight recent advances in the development of detection methods for receptor protein biomarkers using transition metal based approaches, particularly those employing transition metal complexes. We first discuss the strengths and weaknesses of various strategies used for protein biomarker monitoring in live cells. We then describe the principles of the various sensing platforms and their application for receptor protein detection. Finally, we discuss the challenges and future inspirations in this specific field.