Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells. Issue 49 (28th May 2020)

• Record Type: Journal Article
• Authors: Kim, Taehyung; Hyun, Ha Na; Heo, Roun; Nam, Keonwook; Yang, Kyungjik; Kim, Young Min; Lee, Yoon Suk; An, Jae Yoon; Park, Jae Hyung; Choi, Ki Young; Roh, Young Hoon
• Is Part Of: Chemical communications. Volume 56:Issue 49(2020)
• Page Start: 6624
• Page End: 6627
• Publication Date: 2020-05-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc01848a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed. The Dual-PSNP showed significantly enhanced cancer-specific intracellular delivery, gene regulation efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. Abstract : A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.