Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1, 6-a]pyrimidine and pyrimido[1, 6-c]pyrimidine scaffolds. Issue 26 (20th April 2020)

• Record Type: Journal Article
• Authors: Elattar, Khaled M.; Mert, Başak Doğru; Monier, M.; El-Mekabaty, Ahmed
• Is Part Of: RSC advances. Volume 10:Issue 26(2020)
• Page Start: 15461
• Page End: 15492
• Publication Date: 2020-04-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra00411a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The current study provides an overview of the synthetic routes, reactivity and privileged biological characteristics of bicyclic heterocycles incorporating pyrimido[1, 6- a ]pyrimidine and pyrimido[1, 6- c ]pyrimidine cores. Abstract : Heterocycles incorporating a pyrimidopyrimidine scaffold have aroused great interest from researchers in the field of medical chemistry because of their privileged biological activities; they are used as anti-bacterial, antiviral, anti-tumor, anti-allergic, antihypertensive, anticancer, and hepatoprotective agents. Therefore, the present study aims to investigate the chemistry of heterocycles incorporating pyrimido[1, 6- a ]pyrimidine and pyrimido[1, 6- c ]pyrimidine skeletons and their biological characteristics. The main sections discuss (1) the synthetic routes to obtain substituted pyrimidopyrimidines, pyrimido[1, 6- a ]pyrimidin-diones, pyrimidoquinazolines, tricyclic, tetracyclic, and binary systems; (2) the reactivity of the substituents attached to the pyrimidopyrimidine skeleton, including thione and amide groups, nucleophilic substitutions, condensations, ring transformations, and coordination chemistry; (3) compounds of this class of heterocycles containing a significant characteristic scaffold and possessing a wide range of biological characteristics.