Single-wavelength phototheranostics for colon cancer via the thiolytic reaction. Issue 22 (3rd June 2020)

• Record Type: Journal Article
• Authors: Zhu, Yucheng; Chen, Chao; Wu, Qinghua; Yang, Guoliang; Liu, Zhiyong; Hao, Erhong; Cao, Hongliang; Gao, Yun; Zhang, Weian
• Is Part Of: Nanoscale. Volume 12:Issue 22(2020)
• Page Start: 12165
• Page End: 12171
• Publication Date: 2020-06-03
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr02393k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A self-assembled H2 S-specific nanosystem (FR-H2 S) for single-wavelength colon cancer phototheranostics. Abstract : It's a huge challenge to develop effective nanosystems that combine the capabilities of diagnoses and therapies together for colon cancer in the clinic. Herein, we constructed a far-red absorbing phototheranostic nanosystem (FR-H2 S) based on the thiolytic reaction of a dinitrophenyl modified phototheranostic prodrug and over-expressed H2 S in colon cancer sites for precise imaging-guided phototherapy. FR-H2 S with a BODIPY core not only could work as an imaging probe for diagnosis but also act as a phototherapeutic agent for cancer treatment under a single FR laser source (650 nm). FR-H2 S exhibited a gradually enhanced fluorescence emission for precise diagnosis of H2 S-rich colon tumor sites. After entering tumor cells, FR-H2 S could generate abundant 1 O2 and heat for phototherapies timely by using the same laser source (650 nm). We believe that this precise imaging-guided phototheranostic nanosystem could provide a promising approach to colon cancer with minimal damage.