Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides. Issue 43 (24th April 2020)
- Record Type:
- Journal Article
- Title:
- Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides. Issue 43 (24th April 2020)
- Main Title:
- Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides
- Authors:
- Velázquez, Marta
Alberca, Saúl
Iglesias-Sigüenza, Javier
Fernández, Rosario
Lassaletta, José M.
Monge, David - Abstract:
- Abstract : Asymmetric 1, 2-addition of aryl boronic acids to N -carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones affords α-aryl α-hydrazino esters/amides, key building blocks en route to artificial peptides. Abstract : Catalysts generated by combinations of Pd(TFA)2 and pyridine–hydrazone ligands have allowed the asymmetric 1, 2-addition of aryl boronic acids to N -carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding α-aryl α-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides, N -aminopeptides and peptidomimetics thereof.
- Is Part Of:
- Chemical communications. Volume 56:Issue 43(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 43(2020)
- Issue Display:
- Volume 56, Issue 43 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 43
- Issue Sort Value:
- 2020-0056-0043-0000
- Page Start:
- 5823
- Page End:
- 5826
- Publication Date:
- 2020-04-24
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc02478c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13886.xml