Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Issue 19 (10th February 2020)

• Record Type: Journal Article
• Authors: Feng, Yanqiao; Su, Hui; Li, Yunzhi; Luo, Chunxiang; Xu, Huiying; Wang, Youqiao; Sun, Haixia; Wan, Guohui; Zhou, Binhua; Bu, Xianzhang
• Is Part Of: Chemical communications. Volume 56:Issue 19(2020)
• Page Start: 2881
• Page End: 2884
• Publication Date: 2020-02-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08391j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The first proteolysis targeting chimeras for the intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, is described. Abstract : The first proteolysis targeting chimeras for the intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, are described. The appropriately designed DT-6 could efficiently degrade intracellular TGF-β1, and inhibit M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells.