AgNO3-catalyzed decarboxylative cross-coupling reaction: an approach to coenzyme Q. (20th May 2020)

• Record Type: Journal Article
• Authors: Luo, Wan-Yue; Lu, Bin; Qiu, Yong-Fu; Zhou, Rong-Ye; He, Yong-Jing; Wang, Jin
• Is Part Of: New journal of chemistry. Volume 44:Number 21(2020)
• Page Start: 8702
• Page End: 8704
• Publication Date: 2020-05-20
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj01497d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : High yields. Gram-scale synthesis. Csp 2 –H functionalization. Decarboxylative cross-coupling. Abstract : An efficient and general method for the synthesis of coenzyme Q compounds through the activation of the 1, 4-benzoquinone Csp 2 –H bond has been developed. This C–C bond formation reaction proceeds readily in an open flask by the direct cross-coupling reaction of coenzyme Q0 with commercially available aliphatic carboxylic acids utilizing AgNO3 as a catalyst and K2 S2 O8 as an oxidant in aqueous solution. This radical reaction is operationally simple and amenable to gram-scale synthesis.