Manganese(iii)-promoted tandem phosphinoylation/cyclization of 2-arylindoles/2-arylbenzimidazoles with disubstituted phosphine oxides. Issue 25 (17th June 2020)

• Record Type: Journal Article
• Authors: Jiang, Shuai-Shuai; Xiao, Yu-Ting; Wu, Yan-Chen; Luo, Shu-Zheng; Song, Ren-Jie; Li, Jin-Heng
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 25(2020)
• Page Start: 4843
• Page End: 4847
• Publication Date: 2020-06-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00877j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and practical manganese(iii )-promoted tandem phosphinoylation/cyclization of 2-arylindoles/2-arylbenzimidazoles with disubstituted phosphine oxides was developed. Abstract : A simple and practical method for the synthesis of phosphoryl-substituted indolo[2, 1- a ]isoquinolin-6(5 H )-ones and benzimidazo[2, 1- a ]isoquinolin-6(5 H )-ones through manganese(iii )-promoted tandem phosphinoylation/cyclization of 2-arylindoles or 2-arylbenzimidazoles with disubstituted phosphine oxides was developed. In this transformation, new C–P bond and C–C bond were constructed simultaneously under silver-free conditions, exhibiting a broad substrate scope. It was noted that not only diarylphosphine oxides but also dialkyl and arylalkyl-phosphine oxides were compatible with the conditions.