Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4. Issue 7 (12th March 2020)

• Record Type: Journal Article
• Authors: Ming, Wenbo; Liu, Xiaocui; Friedrich, Alexandra; Krebs, Johannes; Budiman, Yudha P.; Huang, Mingming; Marder, Todd B.
• Is Part Of: Green chemistry. Volume 22:Issue 7(2020)
• Page Start: 2184
• Page End: 2190
• Publication Date: 2020-03-12
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d0gc00346h
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : α-Amino cyclic boronates were synthesized from readily available salicylaldehydes, amines, and B2 (OH)4 . The process can be run at room temperature in ethanol, does not require catalysts or additives, and scale up and purification are easy. Abstract : We report here a concise synthesis of α-amino cyclic boronates via multicomponent coupling of readily available salicylaldehydes, amines, and B2 (OH)4 . The process can be carried out at room temperature in ethanol, does not require catalysts or additives, and is easy to scale up. Aminals and ligated boroxines are intermediates in this reaction.