Diselenide-crosslinked zwitterionic nanogels with dual redox-labile properties for controlled drug release. Issue 13 (2nd March 2020)

• Record Type: Journal Article
• Authors: Tian, Yefei; Lei, Miao; Yan, Luke; An, Feifei
• Is Part Of: Polymer chemistry. Volume 11:Issue 13(2020)
• Page Start: 2360
• Page End: 2369
• Publication Date: 2020-03-02
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/d0py00004c
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : We developed a diselenide-crosslinked zwitterionic nanogel based on poly(2-methacryloyloxyethyl phosphorylcholine), which has sensitive dual redox-degradability and high colloidal stability. Abstract : Drug delivery systems developed from zwitterionic polymers have intriguing antifouling properties. Combining these with stimuli-responsiveness, we fabricated a new type of zwitterionic nanogel with dual redox-labile properties by copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and a diselenide bond-containing crosslinker through reflux precipitation polymerization. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-based nanogels show high protein adsorption resistibility and colloidal stability at high salt concentrations. By incorporation of diselenide bonds into polymer networks, the nanogels are endowed with unique dual redox-labile properties that lead to their efficient degradation into short polymers either in a reducing environment (GSH) or in an oxidative environment (H2 O2 ). Nanogels loaded with anticancer drugs (doxorubicin, DOX) display a finely controlled release behavior and low leakage of DOX under physiological conditions (15.0% in 24 h), but rapid and sufficient release under reducing conditions (88.3% in 24 h) or under oxidative conditions (82.2% in 24 h). Cell viability assays reveal that the blank nanogels have no cytotoxicity within a wide concentration range, while DOX-loaded nanogels present a significant inhibitive effect against tumor cells.