Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH. Issue 64 (14th July 2020)

• Record Type: Journal Article
• Authors: Birchall, Jonathan R.; Kabir, Mohammad S. H.; Salnikov, Oleg G.; Chukanov, Nikita V.; Svyatova, Alexandra; Kovtunov, Kirill V.; Koptyug, Igor V.; Gelovani, Juri G.; Goodson, Boyd M.; Pham, Wellington; Chekmenev, Eduard Y.
• Is Part Of: Chemical communications. Volume 56:Issue 64(2020)
• Page Start: 9098
• Page End: 9101
• Publication Date: 2020-07-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc03994b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The presence of 14 N nucleus in the scalar coupling network results in a 3-fold decrease of 15 N T 1 and polarization values for all 15 N sites in 15 N2 -metronidazole versus 15 N3 -metronidazole in SABRE hyperpolarization in microtesla fields. Abstract : 15 N spin–lattice relaxation dynamics in metronidazole- 15 N3 and metronidazole- 15 N2 isotopologues are studied for rational design of 15 N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15 N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14 N nucleus within the spin-relayed 15 N– 15 N network.