Do Lipoid Metabolism Disorders Increase Risks of Maternal and Fetal Complications in Pregnancies? [12N]. (May 2020)

• Record Type: Journal Article
• Authors: Cai, Emmy; Czuzoj-Shulman, Nicholas; Abenhaim, Haim A.
• Is Part Of: Obstetrics and gynecology. Volume 135(2020)Supplement 1
• Publication Date: 2020-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/01.AOG.0000663704.21873.ab
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : INTRODUCTION: The effects of lipoid metabolism disorders (LMD) are not well understood in pregnancy; thus, this study aims at understanding the different maternal and fetal outcomes that can be associated with this condition in pregnancy. METHODS: Using the Healthcare Cost and Utilization Project – National Inpatient Sample from the United States, a retrospective cohort study was conducted to determine the risks of complications in pregnant women known to have LMDs. All pregnant patients diagnosed with LMDs between 1999 and 2015 were identified using the International Classification of Disease-9 coding. Maternal and neonatal outcomes in pregnant women with LMDs were analyzed using multivariate logistic regression. RESULTS: A total of 13, 792, 544 pregnant women were included in our study; 9, 666 women were diagnosed with LMDs for an overall prevalence of 7.0 per 10, 000 births. Births to women with LMDs were more likely to have pregnancies complicated by diabetes and hypertension. Women with LMDs were more likely to have premature births, OR 1.42 (95% CI 1.35–1.53), suffer from myocardial infarctions, 11.97 (6.07–23.58), venous thromboembolisms, 2.03 (1.64–2.51), postpartum hemorrhage, 1.34 (1.21–1.48), and maternal death, 3.52 (1.97–6.32). There was also an increased risk of congenital anomalies, 2.48 (2.09–2.93), intrauterine growth restriction, 1.41 (1.26–1.58), and intrauterine fetal demise, 1.79 (1.51–2.13). CONCLUSION: The effects of LMDs on pregnancies are not very well understood, but women with these disorders appear to be at significantly increased risks of poor maternal and fetal outcomes. Better understanding of these risks and complications can allow for better outcomes in pregnant women suffering from lipoid metabolism disorders.