Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy. Issue 20 (4th May 2020)

• Record Type: Journal Article
• Authors: Zhang, Huaibin; Bo, Shaowei; Zeng, Kai; Wang, Jie; Li, Yu; Yang, Zhigang; Zhou, Xin; Chen, Shizhen; Jiang, Zhong-Xing
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 20(2020)
• Page Start: 4469
• Page End: 4474
• Publication Date: 2020-05-04
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb00083c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics for cancer therapy. Abstract : Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional "add-on" module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/ 19 F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.