Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells. Issue 20 (12th February 2020)

• Record Type: Journal Article
• Authors: Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio
• Is Part Of: Chemical communications. Volume 56:Issue 20(2020)
• Page Start: 3023
• Page End: 3026
• Publication Date: 2020-02-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09993j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Fluorescence imaging of fatty acid beta oxidation (FAO) with a fluorescent probe metabolically degraded by sequential enzyme reactions of FAO. Abstract : Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.