A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water. Issue 36 (8th June 2020)

• Record Type: Journal Article
• Authors: Shah, Syed Raza; Ali, Muhammad; Anwar, Muhammad U.; Al-Harrasi, Ahmed
• Is Part Of: RSC advances. Volume 10:Issue 36(2020)
• Page Start: 21656
• Page End: 21661
• Publication Date: 2020-06-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra03640d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : We have successfully developed a flexible green aqueous approach for the formation of a carbon–carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1, 3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. Abstract : We have successfully developed a flexible green aqueous approach for the formation of a carbon–carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1, 3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized via various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions.