A caged E3 ligase ligand for PROTAC-mediated protein degradation with light. Issue 41 (16th April 2020)
- Record Type:
- Journal Article
- Title:
- A caged E3 ligase ligand for PROTAC-mediated protein degradation with light. Issue 41 (16th April 2020)
- Main Title:
- A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
- Authors:
- Kounde, Cyrille S.
Shchepinova, Maria M.
Saunders, Charlie N.
Muelbaier, Marcel
Rackham, Mark D.
Harling, John D.
Tate, Edward W. - Abstract:
- Abstract : Caging of a widely used Von Hippel Lindau E3 ligase ligand for targeted protein degradation with PROTACs allows light-activated proteolysis. Abstract : With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
- Is Part Of:
- Chemical communications. Volume 56:Issue 41(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 41(2020)
- Issue Display:
- Volume 56, Issue 41 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 41
- Issue Sort Value:
- 2020-0056-0041-0000
- Page Start:
- 5532
- Page End:
- 5535
- Publication Date:
- 2020-04-16
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc00523a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13861.xml