A carboxylate-assisted amination/unactivated C(sp2)–H arylation reaction via a palladium/norbornene cooperative catalysis. Issue 44 (28th April 2020)

• Record Type: Journal Article
• Authors: An, Yang; Zhang, Bo-Sheng; Zhang, Zhe; Liu, Ce; Gou, Xue-Ya; Ding, Ya-Nan; Liang, Yong-Min
• Is Part Of: Chemical communications. Volume 56:Issue 44(2020)
• Page Start: 5933
• Page End: 5936
• Publication Date: 2020-04-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09265j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible with ortho -amination and unactivated C(sp 2 )–H arylation, synthesized a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6 H -benzo[ c ]chromenes. Abstract : This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible with ortho -amination and unactivated C(sp 2 )–H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6 H -benzo[ c ]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp 2 )–H activation, and thus this rate can keep up with the five membered aryl-norbornene–palladacycle (ANP) intermediate.