Three new compounds from the flower branch of Gastrodia elata Blume and anti-microbial activity. Issue 25 (13th April 2020)

• Record Type: Journal Article
• Authors: Yang, Liu; Jiang, Rong; Li, Hui-Hui; Pan, Ya-Ping; Lu, Jing-Jin; Zhang, Hong; Liu, Shou-Jin; Shen, Ji-Lu; Hu, Jiang-Miao
• Is Part Of: RSC advances. Volume 10:Issue 25(2020)
• Page Start: 14644
• Page End: 14649
• Publication Date: 2020-04-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra00965b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Three new compounds (1–3 ): gastrodinol (1 ), 2-(4′-hydroxybenzoyl)-3-hydroxyethyl indole (2 ) and 2-(4′-hydroxybenzoyl)-3-(4′′-hydroxybenzyl)indole (3 ) were isolated from the flower branch of G. elata, and anti-microbial activity. Abstract : Three new compounds (1–3 ), including novel tetra- p -cresol substituted cyclopenta[ a ]naphthalene derivatives, named gastrodinol (1 ), 2-(4′-hydroxybenzoyl)-3-hydroxyethyl indole (2 ), 2-(4′-hydroxybenzoyl)-3-(4′′-hydroxybenzyl)indole (3 ) were isolated from the flower branch of G. elata, along with five known compounds (4–8 ). Among them, compound 1 exhibited the most anti-microbial activity against Streptococcus agalactiae, with the minimum inhibitory concentration of 1 μg ml −1 . This study demonstrated that the novel gastrodinol 1 found in the flower branch of G. elata may be responsible for the anti-microbial effect. It will lead to the development of new antibiotics, and how to utilize the TCM ′′Tianma′′ better.