Visible-light-promoted acyl radical cascade reaction for accessing acylated isoquinoline-1, 3(2H, 4H)-dione derivatives. Issue 10 (26th February 2020)

• Record Type: Journal Article
• Authors: Su, Yingpeng; Zhang, Rong; Xue, Wenxuan; Liu, Xuan; Zhao, Yanan; Wang, Ke-Hu; Huang, Danfeng; Huo, Congde; Hu, Yulai
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 10(2020)
• Page Start: 1940
• Page End: 1948
• Publication Date: 2020-02-26
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00086h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A visible-light-promoted radical acylation/cyclization cascade reaction of N -methacryloylbenzamides with α-keto acids was developed to construct acylated isoquinoline-dione derivatives. Abstract : A visible-light-promoted decarboxylative acyl radical acylation/cyclization cascade reaction of N -methacryloylbenzamides for accessing acylated isoquinoline-1, 3(2 H, 4 H )-dione derivatives was described. In this report, α-keto acids were used for generating acyl radicals and inducing radical acylations. This protocol features mild reaction conditions, operational practicality and a broad substrate scope.