Ni-Catalyzed hydrocyanation of alkenes with formamide as the cyano source. Issue 9 (23rd April 2020)

• Record Type: Journal Article
• Authors: Shu, Xiao; Jiang, Yuan-Yuan; Kang, Lei; Yang, Luo
• Is Part Of: Green chemistry. Volume 22:Issue 9(2020)
• Page Start: 2734
• Page End: 2738
• Publication Date: 2020-04-23
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc04275j
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A novel Ni-catayzed hydrocyanation of various alkenes to provide aliphatic nitriles is developed by generating hydrocyanic acid in situ from safe and readily available formamide. Abstract : "CN" generation from formamide dehydration! A novel Ni-catalyzed hydrocyanation of various alkenes to provide aliphatic nitriles is developed by generating hydrocyanic acid in situ from safe and readily available formamide. Excellent linear or branched regio-selectivity, wide substrate scope, cheap and stable nickel salt as a pre-catalyst, a safe cyano source, slow generation of "CN" to obviate catalyst deactivation and convenient experimental operation would render this hydrocyanation attactive for laboratory synthesis of aliphatic nitriles.