Selective modification of Ti6Al4V surfaces for biomedical applications. Issue 30 (6th May 2020)

• Record Type: Journal Article
• Authors: Rodriguez, Gabriela Melo; Bowen, James; Zelzer, Mischa; Stamboulis, Artemis
• Is Part Of: RSC advances. Volume 10:Issue 30(2020)
• Page Start: 17642
• Page End: 17652
• Publication Date: 2020-05-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra11000c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The surface of a medical implant is required to interact favourably with ions, biomolecules and cells in vivo, commonly resulting in the formation of the extracellular matrix. Abstract : The surface of a medical implant is required to interact favourably with ions, biomolecules and cells in vivo, commonly resulting in the formation of the extracellular matrix. Medical grade Ti6Al4V alloy is widely used in orthopaedic and dental applications for bone replacement due to its advantageous mechanical properties and biocompatibility, which enhances the adhesion between native tissue and the implanted material. In this study, chemical and thermal modification of a medical-grade Ti6Al4V alloy were performed to enhance electrostatic interactions at the alloy surface with a synthetic peptide, suitable for conferring drug release capabilities and antimicrobial properties. The modified surfaces exhibited a range of topographies and chemical compositions depending primarily on the treatment temperature. The surface wetting behaviour was found to be pH-dependent, as were the adhesive properties, evidenced by chemical force titration atomic force microscopy.