Conformationally adaptable macrocyclic receptors for ditopic anions: analysis of chelate cooperativity in aqueous containing media. Issue 27 (25th June 2020)

• Record Type: Journal Article
• Authors: Berry, Stuart N.; Qin, Lei; Lewis, William; Jolliffe, Katrina A.
• Is Part Of: Chemical science. Volume 11:Issue 27(2020)
• Page Start: 7015
• Page End: 7022
• Publication Date: 2020-06-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc02533j
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Chelate cooperativity impacts the binding affinities of dicarboxylates of different sizes to flexible thiourea macrocycles in aqueous DMSO. Abstract : The effect of chelate cooperativity on the binding of several ditopic anions to two tetrathiourea macrocycles has been analysed in competitive solvent mixtures (H2 O : DMSO 1 : 9 v/v). The semi-flexible receptors bind dicarboxylates with high affinity dependent on the length and flexibility of the guest. Chemical double mutant cycle (DMC) analysis allowed the chelate cooperativity effects to be measured in detail and revealed both positive and negative cooperativity effects which were dependent on guest size, flexibility and spacer interactions between guest and macrocycle. 1 H NMR and crystallographic studies confirmed the macrocycle hosts are adaptable, changing conformation to match their pore size to a selected guest.