Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes. Issue 17 (15th April 2020)

• Record Type: Journal Article
• Authors: Derosa, Joseph; Apolinar, Omar; Kang, Taeho; Tran, Van T.; Engle, Keary M.
• Is Part Of: Chemical science. Volume 11:Issue 17(2020)
• Page Start: 4287
• Page End: 4296
• Publication Date: 2020-04-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc06006e
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging multiple C–C bonds in a single step. Abstract : Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging two C–C bonds in a single reaction. Building upon the powerful modes of bond construction in traditional two-component cross-coupling, various research groups have demonstrated the versatility of nickel in enabling catalytic 1, 2-dicarbofunctionalization using a wide range of carbon-based electrophiles and nucleophiles and in a fully intermolecular fashion. Though this area has emerged only recently, the last few years have witnessed a proliferation of publications on this topic, underscoring the potential of this strategy to develop into a general platform that offers high regio- and stereoselectivity. This minireview highlights the recent progress in the area of intermolecular 1, 2-dicarbofunctionalization of alkenes via nickel catalysis and discusses lingering challenges within this reactivity paradigm.