2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site. Issue 59 (23rd June 2020)
- Record Type:
- Journal Article
- Title:
- 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site. Issue 59 (23rd June 2020)
- Main Title:
- 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site
- Authors:
- Bozdag, Murat
Supuran, Claudiu T.
Esposito, Davide
Angeli, Andrea
Carta, Fabrizio
Monti, Simona Maria
De Simone, Giuseppina
Alterio, Vincenzo - Abstract:
- Abstract : 2-Mercaptobenzoxazole represents an interesting lead compound alternative to the classical sulfonamides for the development of selective carbonic anhydrase inhibitors. Abstract : 2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry. By means of kinetic and structural studies, we demonstrate that this molecule can effectively be used to inhibit hCAs showing a peculiar binding mode. The results reported here can pave the way for the development of selective CA inhibitors.
- Is Part Of:
- Chemical communications. Volume 56:Issue 59(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 59(2020)
- Issue Display:
- Volume 56, Issue 59 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 59
- Issue Sort Value:
- 2020-0056-0059-0000
- Page Start:
- 8297
- Page End:
- 8300
- Publication Date:
- 2020-06-23
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc02857f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13848.xml