Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials. Issue 40 (22nd June 2020)

• Record Type: Journal Article
• Authors: Khatoon, Zohra; Guzmán-Soto, Irene; McTiernan, Christopher D.; Lazurko, Caitlin; Simpson, Fiona; Zhang, Li; Cortes, David; Mah, Thien-Fah; Griffith, May; Alarcon, Emilio I.
• Is Part Of: RSC advances. Volume 10:Issue 40(2020)
• Page Start: 23675
• Page End: 23681
• Publication Date: 2020-06-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra03659e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A rapid and precise route to graft a nano-bactericidal barrier is reported. Abstract : We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our in situ grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets.