Structural characterization and anticancer potency of centipede oligopeptides in human chondrosarcoma cancer: inducing apoptosis. Issue 50 (13th August 2020)

• Record Type: Journal Article
• Authors: Ren, Yuebing; Song, Haibo; Wu, Yuanpeng; Ma, Xiaochun; Yu, Xuezhong; Liu, Jia; Sun, Jianhui; Zhang, Zhicheng
• Is Part Of: RSC advances. Volume 10:Issue 50(2020)
• Page Start: 29780
• Page End: 29788
• Publication Date: 2020-08-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra04811a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : CO-10 induced cell apoptosis with mitochondria dysfunction and caspases, ASK1-MAPKs pathway activation. Abstract : Anticancer oligopeptides are rarely studied because they are often present in very low concentrations in a complex matrix. In the current study, twelve oligopeptides were isolated and the amino acid sequence identified from the centipede. MTT results indicated that Trp–Gly–His–Glu (CO-10 ) showed excellent anti-proliferative potency against chondrosarcoma cells in vitro . Further study showed that CO-10 induced SW1353 cells apoptosis and blocked cell cycle in the G0/G1 phase. Further, results demonstrate that the apoptotic and cytotoxic effects of CO-10 are mediated by the intrinsic mitochondria-mediated apoptotic pathway, which in turn causes the release of cytochrome c and the activation of caspases. This study will be important for the development of pharmaceutical anticancer peptides from natural products as anticancer agents against chondrosarcoma.