An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds. Issue 50 (20th May 2020)

• Record Type: Journal Article
• Authors: Stewart, Hannah L.; Hanby, Abigail R.; King, Thomas A.; Bond, Andrew D.; Moss, Thomas A.; Sore, Hannah F.; Spring, David R.
• Is Part Of: Chemical communications. Volume 56:Issue 50(2020)
• Page Start: 6818
• Page End: 6821
• Publication Date: 2020-05-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02728f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A simple, high yielding and scalable synthesis for diastereoselective access to privileged fused bicyclic heteroaromatic scaffolds. Abstract : Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.