An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery. Issue 8 (25th March 2020)

• Record Type: Journal Article
• Authors: Wang, Bo; Wen, Ximiao; Cao, Yan; Huang, Shan; Lam, Hoa A.; Liu, Tingyi "Leo"; Chung, Pei-Shan; Monbouquette, Harold G.; Chiou, Pei-Yu; Maidment, Nigel T.
• Is Part Of: Lab on a chip. Volume 20:Issue 8(2020)
• Page Start: 1390
• Page End: 1397
• Publication Date: 2020-03-25
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/d0lc00021c
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo . Abstract : A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.