An ultra-sensitive T2-weighted MR contrast agent based on Gd3+ ion chelated Fe3O4 nanoparticles. Issue 31 (12th May 2020)

• Record Type: Journal Article
• Authors: Chen, Jing; Xiang, Hui-Hui; Zhao, Zu-Zhi; Wu, Yun-Kai; Fei, Meng-Yu; Song, Meng-Meng
• Is Part Of: RSC advances. Volume 10:Issue 31(2020)
• Page Start: 18054
• Page End: 18061
• Publication Date: 2020-05-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra01807d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An ultra-sensitive T 2 -weighted MR imaging contrast agent was prepared based on Fe3 O4 nanoparticles and Gd 3+ ions (Fe3 O4 @Gd). Abstract : An ultra-sensitive T 2 -weighted MR imaging contrast agent was prepared based on Fe3 O4 nanoparticles and Gd 3+ ions (Fe3 O4 @Gd). Amino modified Fe3 O4 nanoparticles were conjugated to diethylenetriamine pentaacetic acid, and finally coordinated with Gd 3+ ions. The nanoparticles had a uniform morphology with a size of 100 nm and a Gd/Fe mass ratio of 1/110. The r 2 (transverse relaxivity) of the Fe3 O4 nanoparticles increased from 131.89 mM −1 s −1 to 202.06 mM −1 s −1 after coordination with Gd 3+ ions. MR measurements showed that the aqueous dispersion of Fe3 O4 @Gd nanoparticles had an obvious concentration-dependent negative contrast enhancement. Hepatoma cells were selected to test the cytotoxicity and MR imaging effect. The application of Fe3 O4 @Gd nanoparticles as contrast agents was also exploited in vivo for T 2 -weighted MR imaging of rat livers. All the results showed the effectiveness of the nanoparticles in MR diagnosis.