Asymmetric synthesis of spirooxindole–pyranoindole products via Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring. (2nd June 2020)

• Record Type: Journal Article
• Authors: Gao, Yuan; Wang, Xiaonan; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Lin, Yingjie; Duan, Haifeng
• Is Part Of: New journal of chemistry. Volume 44:Number 23(2020)
• Page Start: 9788
• Page End: 9792
• Publication Date: 2020-06-02
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj00074d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Enantioselective Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring with isatylidene malononitriles was performed using a new bifunctional catalyst. Abstract : An efficient enantioselective Friedel–Crafts alkylation/cyclization tandem reaction of the indole carbocyclic ring with isatylidene malononitriles has been performed successfully by using a new bifunctional tertiary amine-urea catalyst. A series of chiral spirooxindole–pyranoindole products were obtained in excellent yields (up to 98% yield) with moderate to good enantioselectivities (up to 85% ee).