Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation. Issue 52 (27th May 2020)

• Record Type: Journal Article
• Authors: Yuan, Xiushuang; Jiang, Linhai; Chen, Weike; Song, Bo; Chen, Wei; Zuo, Xiaobing; Sun, Xiankai; Li, Xiaopeng; Kirshenbaum, Kent; Luo, Shizhong; Dong, He
• Is Part Of: Chemical communications. Volume 56:Issue 52(2020)
• Page Start: 7128
• Page End: 7131
• Publication Date: 2020-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02066d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : In this work, we report the self-assembly of chimeric peptides in which two distinctly folded domains can be organized into a finite peptide hexamer with precise control over multivalent ligand presentation and enhanced tumor cell targeting. Abstract : This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.