Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications. Issue 55 (9th June 2020)

• Record Type: Journal Article
• Authors: Mao, Xianxian; Li, Wei; Zhu, Shiyu; Zou, Juan; Tian, Hongyan; Duan, Yuting; Wang, Yuntao; Fei, Jiayue; Wang, Xiaojian
• Is Part Of: Chemical communications. Volume 56:Issue 55(2020)
• Page Start: 7601
• Page End: 7604
• Publication Date: 2020-06-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02722g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bifunctional pyridoxal derivatives were developed and applied for a variety of bioorthogonal applications. Abstract : Two types of pyridoxal analogs, azido pyridoxal (PL-N3 ) and carboxyl pyridoxal (PL-COOH), were developed as novel bifunctional bioorthogonal molecules. These molecules showed fast imine formation with hydrazinyl groups and stable covalent linkages via azido/carboxyl groups, and thus were of great use for site-specific peptide and protein modifications.