Rhizovagine A, an unusual dibenzo-α-pyrone alkaloid from the endophytic fungus Rhizopycnis vagum Nitaf22. Issue 47 (27th July 2020)

• Record Type: Journal Article
• Authors: Wang, Ali; Zhao, Siji; Gu, Gan; Xu, Dan; Zhang, Xuping; Lai, Daowan; Zhou, Ligang
• Is Part Of: RSC advances. Volume 10:Issue 47(2020)
• Page Start: 27894
• Page End: 27898
• Publication Date: 2020-07-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra05022a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Rhizovagine A (1 ), a dibenzo-α-pyrone alkaloid with a 5/5/6/6/6 fused pentacyclic skeleton and acetylcholinesterase inhibitory activity, was isolated from the endophytic fungus Rhizopycnis vagum Nitaf22. Abstract : Rhizovagine A (1 ), a novel dibenzo-α-pyrone alkaloid with an unprecedented 5/5/6/6/6 fused pentacyclic skeleton, was isolated from the endophytic fungus Rhizopycnis vagum Nitaf22. The structure was elucidated by comprehensive spectroscopic analysis, in combination with quantum chemical 13 C NMR and electronic circular dichroism (ECD) calculations for configurational assignment. A plausible biosynthetic pathway for 1 was proposed. Compound 1 displayed acetylcholinesterase inhibitory activity.