Access to SCN-containing thiazolines via electrochemical regioselective thiocyanothiocyclization of N-allylthioamides. Issue 11 (23rd April 2020)

• Record Type: Journal Article
• Authors: Zhang, Yan-An; Ding, Zhong; Liu, Peng; Guo, Wei-Si; Wen, Li-Rong; Li, Ming
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 11(2020)
• Page Start: 1321
• Page End: 1326
• Publication Date: 2020-04-23
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00300j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An electrochemical thiocyclization of N -allylthioamides has been developed for the synthesis of SCN-containing 2-thiazolines and NCS-containing thiazines. Abstract : An electrochemical thiocyanothiocyclization of N -allylthioamides has been developed for the synthesis of SCN-containing 2-thiazolines. This method provides a green and efficient approach to generate 5- ex o-cyclization 2-thiazolines with a broad substrate scope and good yields. In addition, 6- endo -cyclization isothiocyanato thiazines are formed regioselectively when cyclic thioamides are used as reactants. The reaction is easy to proceed under catalyst-, additive- and oxidant-free conditions.